Early Trajectory Of Alzheimer’s Tracked In Single-cell Brain Atlases
Specific gene network modules upregulated or. A team of researchers led by dr. Here we use multiomics, spatial genomics and reference atlases from the brain initiative to study middle temporal gyrus cell types in 84 donors with varying ad pathologies. The current study harnesses single cell and spatial genomics tools and knowledge from the brain initiative cell census network to understand the impact of disease progression on middle temporal gyrus cell types and mapped single nuclei from each donor to a common. Alzheimer's disease (ad) is the most common cause of dementia worldwide, but the molecular and cellular mechanisms underlying cognitive impairment remain poorly.